Clusters of galaxies are expected to contain substantial population of cosmic-rays that can yield a significant high energy emission. Moreover, as they are heavily dark matter dominated, they must be considered prime targets for gamma-ray searches for WIMP decay or annihilation. I will present dark matter gamma-ray all-sky simulated Fermi maps of the Local Universe. The dark matter distribution is obtained from a constrained cosmological simulation provided by the CLUES project. I will discuss the possibility for the Fermi-LAT instrument to detect a dark matter gamma-ray signal in extragalactic structures, mainly nearby clusters, in a 5-year all-sky survey and discuss our on work in progress on cosmic-rays. We are also promoting a campaign of observation of the Perseus galaxy cluster with the MAGIC telescopes. Deep observations of nearby clusters with ground-based instruments are crucial to investigate the nature of dark matter as well as the possible gamma-ray emission coming from cosmic-ray acceleration in these environments.