The implementation of Adaptive Optics at the GTC, combined with the science instrument FRIDA -- an imager and integral field spectrograph operating in the near-infrared —- represents a factor of 10 to 15 improvement in angular resolution compared to current or planned GTC instruments. These resolutions are still a factor of 1.5 to 4 better than those achieved by the finest space telescopes, JWST and HST. This presentation highlights the imminent realisation of these capabilities at the GTC and the unique scientific opportunities enabled by the GTC+AO+FRIDA combination. To this end, I will outline possible science pathways that are uniquely possible with GTC+AO+FRIDA, ranging from stellar surface mapping to studies of the Local Group at the finest spatial scales and the high-redshift Universe.